李毅，男，博士，副教授，硕士研究生导师。2014年博士毕业于中山大学。湖南省优秀硕士论文指导老师、湘潭市高层次人才。主要研究方向为过渡金属配合物的抗肿瘤及生物成像研究。近年来，先后共主持国家自然科学基金，湖南省自然科学基金，中国博士后基金等项目。以第一作者或通讯作者在Advanced Materials、Journal of Medicinal Chemistry、Biomaterials、Journal of Colloid and Interface Science、Applied Materials Today、Sensors and Actuators B: Chemical、Microchemical Journal、Analytica Chimica Acta等重要学术期刊上发表论文30余篇，论文被引1700余次（H-index=17），获发明专利4项。
2005年09月—2009年06月 吉首大学，学士
2009年09月—2014年12月 中山大学（硕博连读），博士
2015年01月—2017年07月 中山大学中山医学院，博士后
2017年07月—2018年12月 湖南科技大学
2018年12月—至今 湖南科技大学，副教授
《无机化学》《普通化学》《无机化学实验》
[1] 湖南省自然科学基金，2025JJ50125，2025.01-2027.12，主持。
[2] 湖南省教育厅科学基金，24B0456，2024.12-2027.12，主持。
[3] 湖南省自然科学基金，2019JJ50188，2019.01-2021.12，主持。
[4] 国家自然科学基金青年基金，21601210，2017.01-2019.12，主持。
[5] 中国博士后科学基金，2015M572397，2015.01-2016.12，主持。
第一作者或通讯作者论文：
[1] Xu Han, Fan Feng, Zixu Wang, Shujun Huang, Kaiyan Xi, Zezheng Fang, Jianyu Shen, Mingrui Wang, Yi Zhang, Ben Liu, Junpeng Wang, Jiahao Wang, Xiangjun Liang, Guangpan Sun, Runlu Zhang, Baoteng Han, Fanlin Liu, Mingze Li, Xun Zhang, Jingjing Wang, Huimin Geng, Yanrong Zhang, Wenli Zhang, Zimei Wu, Xingang Li, Yi Li,* Lian Cheng,* Yulin Zhang,* and Shilei Ni.* Preventing Glioblastoma Relapse by Igniting Innate Immunity through Mitochondrial Stress in the Surgical Cavity. Adv. Mater. 2025, e11351.
[2] Wei Wu, Jiali Liu, Ben Liu,* Rui Chen, Yi Li,* Jing Sun.* Mitochondria-fixable hydrogen sulfide probe based on iridium complex for cancer-specific imaging. Microchem J. 2025, 217, 114997.
[3] Xinlan Zhou, Xinzhong Ruan, Xingjiang Li, Weiyuan Xu, Xinhui Xiao, Aiyi Chen, Yinghui Ding, Jilai Zhang, Gengshen Mo, Yong Jian, Xinyang Wu, Fangfu Ye, Zhiqiang Wang*, Yi Li*, Lixiong Dai*. Chiral Strategy for Developing High-Performance Polymeric Gadolinium-Based MRI Contrast Agents for Vascular and Tumor Imaging. Chem. Biomed. Imaging 2025, 3, 387-397.
[4] Jianguo Zheng, Aijing Zhang, Qinglong Du, Chi Li, Zhongwei Zhao, Luchao Li, Zhao Zhang, Xin Qin, Yi Li*, Kang-Nan Wang*, Nengwang Yu*. Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy. J. Colloid Interf. Sci., 2025, 683, 420-431.
[5] Yi Li*, Ben Liu, Yue Zheng, Meng Hu, Liu-Yi Liu, Cai-Rong Li, Wei Zhang*, Yu-Xiao Lai*, and Zong-Wan Mao*. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy. J. Med. Chem., 2024, 67, 16235?16247.
[6] Meng Hu, Xin-Lan Zhou, Tian-Xin Xiao, Liang Hao*, Yi Li*. Inducing and monitoring mitochondrial pH changes with an iridium (III) complex via two-photon lifetime imaging. Dalton Trans., 2023, 52, 15859–15865.
[7] Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li*, Yibo Zhou*, Monitoring H2S fluctuation during autophagic fusion of lysosomes and mitochondria using a lysosome-targeting fluorogenic probe. Anal. Chim. Acta 2023, 1265, 341356.
[8] Ben Liu, Jing Long, Meng Zhang, Kaiming Cheng, Xin Gao, Yibo Zhou, Yi Li *, Zilong Tang*, Wei Zhang*. Mitochondria-targeted phosphorescent cyclometalated iridium(III) complex for bioimaging of H2S. J. Inorg. Biochem., 2022, 226, 111626.
[9] Ben Liu, Zhiyin Chen, Yu Li, Xiang-Fu Du, Wenjing Zhang, Wei Zhang,* Yuxiao Lai* and Yi Li*. Brominated cyclometalated iridium(III) complexes for mitochondrial immobilization as potential anticancer agents. Dalton Trans., 2022, 51, 7650–7657.
[10] Ben Liu, Xu Huang, Meng Hu, Zhiyin Chen, Wei Zhang* and Yi Li*. Mitochondria?targeted cyclometalated iridium (III) complex for H2S-responsive intracellular redox regulation as potent photo-oxidation anticancer agent. J. Biol. Inorg. Chem., 2022, 27, 641–651.
[11] Xiang-Fu Du#, Yi Li# (共同第一作者), Jing Long, Wei Zhang*, Dou Wang, Cai-Rong Li , Mei-Xia Zhao*, Yuxiao Lai,* Fabrication of cisplatin-loaded polydopamine nanoparticles via supramolecular self-assembly for photoacoustic imaging guided chemo-photothermal cancer therapy. Appl. Mater. Today 2021, 23, 101019.
[12] Wei Zhang,# Yi Li# (共同第一作者), Lanju Xu,† Dou Wang, Jing Long, Meng Zhang, Yufei Wang, Yuxiao Lai* and Xing-Jie Liang.* Near-Infrared-Absorbing Conjugated Polymer Nanoparticles Loaded with Doxorubicin for Combinatorial Photothermal- Chemotherapy of Cancer. ACS Appl. Polym. Mater. 2020, 2, 4180−4187.
[13] Yi Li,* Ben Liu, Cui-Xia Xu, Liang He, Yi-Chao Wan, Liang-Nian Ji and Zong-Wan Mao*. Mitochondria-targeted phosphorescent cyclometalated iridium(III) complexes: Synthesis, characterization and anticancer properties. J. Biol. Inorg. Chem., 2020, 25, 597-607.
[14] Yi Li, Kang-Nan Wang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. J. Inorg. Biochem., 2020, 205, 110976.
[15] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Mitochondria-targeted two-photon fluorescent probe for the detection of biothiols in living cells. Sensor. Actuat. B-Chem., 2018, 255, 193-202.
[16] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) N-heterocyclic carbene complexes as potential mitochondrial anticancer and photodynamic agents. Dalton Trans., 2017, 46, 11363-11371.
[17] Yi Li, Cai-Ping Tan, Wei Zhang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials 2015, 39, 95-104.
[18] Yi Li, Gao-Feng Liu,* Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*, Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6, 1460-1468.
[1] 李毅，肖田鑫，周欣斓，刘奔。一种线粒体DNA靶向铱配合物的制备方法及其抗肿瘤应用。专利号：ZL202311031011.1；授权时间：2025 年08 月26 日。
[2] 李毅，刘奔，胡梦。一种诱导铁死亡的双核铱配合物的制备方法及其应用。专利号：ZL202210485441.X；授权时间：2023年12月26日。
[3] 李毅，刘奔，雷欢，阿依古丽·麦麦提图尔荪。一种基于香豆素的硫化氢荧光探针及其制备方法和应用。专利号：ZL202010667152.2；授权时间：2022年9月30日。
[4] 李毅，刘奔，高鑫，王豆，郑湘兰。一种环金属铱配合物探针及其制备方法和应用。专利号：ZL201911255436.4；授权时间：2022年5月13日。