李毅，男，1986年9月出生，博士，副教授，博士研究生导师。2014年博士毕业于中山大学。湖南省优秀硕士论文指导老师、湘潭市高层次人才、湖南科技大学“奋进学者”（青年创新人才）。主要研究方向为过渡金属配合物的抗肿瘤及生物成像研究。近年来，先后共主持国家自然科学基金，湖南省自然科学基金，中国博士后基金等项目。在Journal of Medicinal Chemistry、Biomaterials、Chemical Science、Chemical Communications、Sensors and Actuators B: Chemical、Dalton Transactions等重要学术期刊上发表论文30余篇，论文被引1600余次，获发明专利3项。
2005年09月—2009年06月 吉首大学，学士
2009年09月—2014年12月 中山大学（硕博连读），博士
2015年01月—2017年07月 中山大学中山医学院，博士后
2017年07月—2018年12月 湖南科技大学
2018年12月—至今 湖南科技大学，副教授
《无机化学》《普通化学》《无机化学实验》
[1] 国家自然科学基金青年基金，21601210，2017.01-2019.12，主持。
[2] 湖南省自然科学基金，2019JJ50188，2019.01-2021.12，主持。
[3] 中国博士后科学基金，2015M572397，2015.01-2016.12，主持。
[1] Yi Li*, Ben Liu, Yue Zheng, Meng Hu, Liu-Yi Liu, Cai-Rong Li, Wei Zhang*, Yu-Xiao Lai*, and Zong-Wan Mao*. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S‑Responsive Iridium(III) Complex for Cancer-Specific Therapy. J. Med. Chem., 2024, 67, 16235−16247.
[2] Meng Hu, Xin-Lan Zhou, Tian-Xin Xiao, Liang Hao*, Yi Li*. Inducing and monitoring mitochondrial pH changes with a iridium (III) complex via two-photon lifetime imaging. Dalton Trans., 2023, 52, 15859–15865.
[3] Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li,* Yibo Zhou, * Monitoring H2S fluctuation during autophagic fusion of lysosomes and mitochondria using a lysosome-targeting fluorogenic probe. Anal. Chim. Acta 2023, 1265, 341356.
[4] Ben Liu, Jing Long, Meng Zhang, Kaiming Cheng, Xin Gao, Yibo Zhou, Yi Li *, Zilong Tang*, Wei Zhang*. Mitochondria-targeted phosphorescent cyclometalated iridium(III) complex for bioimaging of H2S. J. Inorg. Biochem., 2022, 226, 111626.
[5] Ben Liu, Zhiyin Chen, Yu Li, Xiang-Fu Du, Wenjing Zhang, Wei Zhang,* Yuxiao Lai* and Yi Li*. Brominated cyclometalated iridium(III) complexes for mitochondrial immobilization as potential anticancer agents. Dalton Trans., 2022, 51, 7650–7657.
[6] Ben Liu, Xu Huang, Meng Hu, Zhiyin Chen, Wei Zhang* and Yi Li*. Mitochondria‑targeted cyclometalated iridium (III) complex for H2S‑responsive intracellular redox regulation as potent photo‑oxidation anticancer agent. J. Biol. Inorg. Chem., 2022, 27, 641–651.
[7] Xiang-Fu Du#, Yi Li # (共同第一作者), Jing Long, Wei Zhang*, Dou Wang, Cai-Rong Li , Mei-Xia Zhao*, Yuxiao Lai,* Fabrication of cisplatin-loaded polydopamine nanoparticles via supramolecular self-assembly for photoacoustic imaging guided chemo-photothermal cancer therapy. Appl. Mater. Today 2021, 23, 101019.
[8] Wei Zhang,# Yi Li# (共同第一作者), Lanju Xu,? Dou Wang, Jing Long, Meng Zhang, Yufei Wang, Yuxiao Lai* and Xing-Jie Liang.* Near-Infrared-Absorbing Conjugated Polymer Nanoparticles Loaded with Doxorubicin for Combinatorial Photothermal- Chemotherapy of Cancer. ACS Appl. Polym. Mater. 2020, 2, 4180?4187.
[9] Yi Li,* Ben Liu, Cui-Xia Xu, Liang He, Yi-Chao Wan, Liang-Nian Ji and Zong-Wan Mao*. Mitochondria-targeted phosphorescent cyclometalated iridium(III) complexes: Synthesis, characterization and anticancer properties. J. Biol. Inorg. Chem., 2020, 25, 597-607.
[10] Yi Li, Kang-Nan Wang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. J. Inorg. Biochem., 2020, 205, 110976.
[11] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Mitochondria-targeted two-photon fluorescent probe for the detection of biothiols in living cells. Sensor. Actuat. B-Chem., 2018, 255, 193-202.
[12] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) N-heterocyclic carbene complexes as potential mitochondrial anticancer and photodynamic agents. Dalton Trans., 2017, 46, 11363-11371.
[13] Yi Li, Cai-Ping Tan, Wei Zhang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials 2015, 39, 95-104.
[14] Yi Li, Gao-Feng Liu,* Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*, Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6, 1460-1468.
[15] Liang He, Yi Li, Cai-Ping Tan,* Rui-Rong Ye, Mu-He Chen, Jian-Jun Cao, Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) complexes as lysosome targeted photodynamic anticancer and real-time tracking agents. Chem. Sci., 2015, 6, 5409-5418.
[16] Qian Cao, Yi Li, Eva Freisinger, Peter Z. Qin,* Roland K. O. Sigel,* and Zong-Wan Mao*, G-Quadruplex DNA Targeted Metal Complexes Acting as Potential Anticancer Drugs. Inorg. Chem. Front., 2017, 4, 10-32.