万义超,男,1988年生,博士,副教授,硕士生导师,湖南科技大学“湘江学者”拔尖人才,现为湖南科技大学化学化工学院专任教师。主要从事基于靶点结构的药物设计、合成及生物活性研究和化学生物学的研究。近年来主持或参与国家自然科学基金、湖南省自然科学基金、湖南省教育厅基金等项目10余项。在J. Med. Chem.、J. Org. Chem.、Eur. J. Med. Chem.、Bioorg. Chem.、Bioorg. Med. Chem. 等国内外知名期刊上发表论文20余篇(高被引论文1篇)。授权发明专利4项,其中国际专利1项。先后指导大学生研究性学习和创新性实验项目、SRIP项目等,获得湖南省第十一届大学生化学化工学科竞赛一等奖、湖南省第十四届研究生创新论坛三等奖、第十四届湖南科技大学节能减排社会实践与科技竞赛三等奖等,指导的研究生1人获国家奖学金1次,校优秀研究生2次,此外还获得2023度优秀班主任称号。
2011/09-2016/06,山东大学,药学院药物化学系,博士(硕博连读)
2007/09-2011/06,海南大学,海洋学院制药工程,学士
2016.7-2021.12, 湖南科技大学, 理论有机化学与功能分子教育部重点实验室, 讲师
2022.1-2024.12,湖南科技大学, 理论有机化学与功能分子教育部重点实验室, 副教授
2025.1-至今,湖南科技大学, 化学化工学院, 副教授
《有机化学实验》、《药理学》、《药物化学》、《生物制药基础》、《无机及分析化学实验》等
[1] 国家自然科学基金青年基金:新型含氮杂环类Bcl-2/Mcl-1双靶点抑制剂的设计、合成及生物活性研究(82003602),2021.01-2023.12. (主持)
[2] 湖南省自然科学基金面上项目:新型含氮杂环类HDAC/Mcl-1双靶点抑制剂的设计、合成及生物活性研究(2023JJ30270),2023.01-2025.12(主持)
[3] 湖南省自然科学基金青年基金,新型吲唑类Bcl-2/Mcl-1双重抑制剂的设计、合成及生物活性研究(2019JJ50145),2019.01-2021.12. (主持)
[4] 湖南省教育厅重点项目,针对HDAC和Mcl-1的新型双靶点抑制剂的设计、合成及生物活性研究(24A0358),2024.12-2027.012.(主持)
[5] 湖南省教育厅优秀青年基金,针对Mcl-1蛋白的新型小分子抗肿瘤化合物的设计、合成及生物活性研究(21B0478),2022.01-2024.012.(主持)
[6] 湖南省教育厅科研项目一般项目,新型小分子Bcl-2/Mcl-1双靶点抑制剂的设计、合成及生物活性研究(18C0325),2018.09-2020.12. (主持)
[7] 湖南科技大学博士科研基金,新型吲哚类衍生物的设计、合成及抗肿瘤活性研究(E51765),2018.01-2019.12. (主持)
[8] 理论有机化学与功能分子教育部重点实验室开放课题项目:新型1,3,4-噁二唑衍生物的设计、合成及抗肿瘤活性研究(E21746),2017.01-2018.12。(主持)
[9] 理论有机化学与功能分子教育部重点实验室开放课题项目:新型2,4-噻唑啉二酮衍生物的设计、合成及抗肿瘤活性研究(LKF202105),2021.01-2022.12。(主持)
[10] 湖南省湖湘高层次人才聚集工程(创新团队),杂环及金属配合物类药物研发创新团队(2021RC5028),2021.09-2024.09. (参与)
[11] 国家自然科学基金面上项目,新型CYP51和SDH双靶点酰胺类杀菌剂的设计合成及构效关系研究(21877034),2019.01-2022.12。(参与)
[12] 国家自然科学青年基金,铜催化C-H键活化与自由基介导构筑C-C键的反应研究(21703061),2018.01-2020.12。(参与)
[13] 国家自然科学基金面上项目,设计、合成具有HDAC和Bcl-2双重抑制作用的新型抗肿瘤药物(81373281),2014.01-2017.12。(参与)
1. Hongjuan Chen , Zixue Yan , Changqing Xiao , Zilong Tang**, Yichao Wan*, Recent advances of small-molecule Mcl-1 inhibitors or degraders as promising anti-cancer agents (2018-present), European Journal of Medicinal Chemistry, 2025, 299, 118079.
2. Jiabing Long, Hongjuan Chen, Zixue Yan, Le Zhou, Ritian Deng, Jie Wang, Zilong Tang, Yichao Wan*, Discovery and development of thiazolidine-2,4-dione derivatives as Bcl-2/Mcl-1 dual inhibitors, Bioorganic Chemistry, 2024, 151, 107687.
3. Yongyan Luo, Yanyan Zhang, Mengting Liu, Xiaozhen Wang, Yichao Wan*, Shujun Cao*, Photoredox/Copper-Cocatalyzed Domino Annulation of Oxime Esters and NH4SCN: Access to Fully Substituted 2‑Aminothiazoles, The Journal of Organic Chemistry, 2024, 89, 15187-15196.
4. Guoqing Fang, Hongjuan Chen, Zhiyun Cheng, Zilong Tang, Yichao Wan*, Azaindole derivatives as potential kinase inhibitors and their SARs elucidation, European Journal of Medicinal Chemistry, 2023, 258, 115621.
5. Zilong Tang*, Yuhuan Tan, Hongjuan Chen, Yichao Wan*, Benzoxazine: A Privileged Scaffold in Medicinal Chemistry, Current Medicinal Chemistry, 2023, 30, 372-389.
6. Xi Luo, Xu Deng, Jingyi Ruan, Wenyan Wang, Yichao Wan*, Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Indazole Derivatives as Bcl-2/Mcl-1 Dual Inhibitors, Russian Journal of General Chemistry, 2022, 92, 1109-1114.
7. Xu Deng, Jiabing Long, Wenyan Wang, Shen Xia, Yichao Wan*, Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Thiazolidine-2,4-dione Derivatives as Mcl-1 Inhibitors, Russian Journal of General Chemistry, 2022, 92, 464-469.
8. Yichao Wan*, Guoqing Fang, Hongjuan Chen, Xu Deng, Zilong Tang, Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation, European Journal of Medicinal Chemistry, 2021, 226, 113837.
9. Yichao Wan*, Jiabing Long, Han Gao, Zilong Tang, 2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer, European Journal of Medicinal Chemistry, 2021, 210, 112953.
10. Han Gao, Yichao Wan*, Yuhuan Tan, Xi Luo, Lin Li, Synthesis and Antifungal Activity of New N-Aryl-2-(2-hydroxyphenylamino) ethylenediamine Derivatives, Russian Journal of General Chemistry, 2021, 91, 122-127.
11. Fen Huang, Wenjie Jiao, Yichao Wan*, Synthesis and Anti-Fungal Activity of New 3-Aryl-1,3-benzoxazine-2-ketone Derivatives, Russian Journal of General Chemistry, 2021, 91, 1112-1116.
12. Tingting Liu*, Yichao Wan, Yuliang Xiao, Chengcai Xia, Guiyun Duan, Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy,Journal of Medicinal Chemistry, 2020, 63, 8977-9002.
13. Yichao Wan*, Yuanhua Li, Chunxing Yan, Jiajun Wen, Zilong Tang, Discovery of novel indazole-acylsulfonamide hybrids as selective Mcl-1 inhibitors, Bioorganic Chemistry, 2020, 104, 104217.
14. Yichao Wan*, Chunxing Yan, Han Gao, Tingting Liu**, Small-molecule PROTACs: novel agents for cancer therapy, Future Medicinal Chemistry, 2020, 12: 915-938
15. Yichao Wan*, Wei Li, Zipeng Liao, Mi Yan, Xuwang Chen, Zilong Tang**, Selective MMP-13 inhibitors: promising agents for the therapy of Osteoarthritis, Current Medicinal Chemistry, 2020, 27, 3753-3769.
16. Yichao Wan*, Yuanhua Li, Chunxing Yan, Mi Yan, Zilong Tang**, Indole: A privileged scaffold for the design of anti-cancer agents, European Journal of Medicinal Chemistry, 2019, 183, 111691.
17. Yichao Wan*, Yuanhua Li, Zhipeng Liao, Zilong Tang, Yi Li, Yunhui Zhao, Bin Xiong, A new xanthene-based fluorescent probe with a red light emission for selectively detecting glutathione and imaging in living cells, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 223, 117265.
18. Yichao Wan, Ningning Dai, Zilong Tang, Hao Fang*, Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents, European Journal of Medicinal Chemistry, 2018, 146, 471-482.
19. Yichao Wan*, Shengzhuo He, Wei Li, Zilong Tang, Indazole Derivatives: Promising Anti-tumor Agents, Anti-Cancer Agents in Medicinal Chemistry, 2018, 18, 1228-1234.
20. Yichao Wan, Tingting Liu, Xiaoxian Li, Chen Chen, Hao Fang*, Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains, Bioorganic & Medicinal Chemistry, 2017, 25, 138-152.
21. Yichao Wan, Junhua Wang, Feng’e Sun, Minglu Chen, Xuben Hou, Hao Fang*, Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors, Bioorganic & Medicinal Chemistry, 2015, 23, 7685-7693.
22. Yichao Wan, Shaolei Wu, Guizhi Xiao, Tingting Liu, Xuben Hou, Chen Chen, Peng Guan, Xinying Yang, Hao Fang*. Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. Bioorganic & Medicinal Chemistry, 2015, 23, 1994-2003.
[1] 万义超, 龙家兵, 邓旭, 陈红娟,取代3-噻唑烷-2,4-二酮类Mcl-1蛋白抑制剂及制备方法和应用,
ZL202211126988.7。(中国)
[2] 万义超、廖志鹏、全椰岑、李玮、袁林,一种氧杂蒽类荧光探针及其制备方法和应用,
ZL201811190426.2。(中国)
[3] 万义超,李园华,闫春兴,温佳俊,取代3-吲哚类Mcl-1蛋白抑制剂及制备方法和应用,ZL202010434371.6。(中国)
[4] WAN, Yichao; LI, Yuanhua; YAN, Chunxing and WEN, Jiajun, Substituted 3-Indazole MCL-1 Inhibitor, Preparation Method and Use Thereof, 2021100660 (澳大利亚)。
1. 基于靶点的抗肿瘤药物的设计、合成及活性研究;
2. 小分子荧光探针的设计及生物成像;
3. 有机合成方法学。